VIROLOGY • IMMUNOLOGY • COUNTERMEASURES
Uncovering the mechanisms of emerging RNA virus infection, transmission, and pathogenesis.
The Case Lab investigates how emerging RNA viruses cause disease, interact with the host immune system, and can be mitigated through vaccines, monoclonal antibodies, and other countermeasures. Our work bridges basic virology and translational immunology to address urgent threats to global health.
Photo credit: Matt Miller/WashU Medicine
OUR APPROACH
A modular platform for emerging virus research.
Shared experimental frameworks allow deep mechanistic work and rapid response to newly emerging threats.
Mechanistic virology
Reverse genetics, host restriction, tissue tropism, and viral adapation.
In vivo pathogenesis
Small-animal models of infection, immunity, disease, and transmission.
Immune profiling
Humoral, cellular, systemic, and mucosal correlates of protection.
Translational countermeasures